Rafael León Selected Research

ethyl 5- amino- 6,7,8,9- tetrahydro- 2- methyl- 4- phenylbenzo(1,8)naphthyridine- 3- carboxylate

9/2004

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.

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Rafael León Research Topics

Disease

11	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 12/2006
8	Neuroinflammatory Diseases 12/2021 - 01/2015
7	Neuroblastoma 01/2022 - 09/2004
5	Inflammation (Inflammations) 01/2022 - 11/2009
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 01/2015
5	Brain Ischemia (Cerebral Ischemia) 04/2017 - 12/2015
3	Neoplasms (Cancer) 10/2021 - 11/2009
3	Ischemia 01/2018 - 03/2014
3	Stroke (Strokes) 04/2017 - 03/2014
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 01/2021
2	Infarction (Infarctions) 12/2015 - 03/2014
1	Carcinoma (Carcinomatosis) 10/2021
1	HIV Infections (HIV Infection) 01/2021
1	Retinal Degeneration 02/2020
1	Retinitis Pigmentosa (Pigmentary Retinopathy) 02/2020
1	Blindness (Hysterical Blindness) 02/2020
1	Ventilator-Associated Pneumonia 01/2020
1	Cognitive Dysfunction 08/2019
1	Tauopathies 08/2019
1	Proteostasis Deficiencies 08/2019
1	Hemolysis 01/2019
1	Fibrosarcoma 10/2018
1	Astrocytoma (Pilocytic Astrocytoma) 01/2018
1	Chronic Disease (Chronic Diseases) 01/2018
1	Hypertension (High Blood Pressure) 08/2017
1	Atherosclerosis 08/2017
1	Vascular Diseases (Vascular Disease) 08/2017
1	Sepsis (Septicemia) 01/2017
1	Septic Shock (Toxic Shock Syndrome) 01/2017
1	Bacteremia 01/2017

Drug/Important Bio-Agent (IBA)

8	AntioxidantsIBA 07/2020 - 03/2014
6	MelatoninIBA 08/2019 - 03/2014
5	Neuroprotective AgentsIBA 01/2022 - 12/2006
5	Oxygen (Dioxygen)IBA 01/2018 - 05/2014
5	Glucose (Dextrose)FDA LinkGeneric 01/2018 - 05/2014
4	Okadaic AcidIBA 01/2022 - 06/2011
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 01/2018
4	Proteins (Proteins, Gene)FDA Link 08/2020 - 01/2015
4	Tacrine (Cognex)FDA Link 11/2016 - 12/2006
3	1,4-dihydropyridine (dihydropyridine)IBA 07/2020 - 12/2006
3	CalciumIBA 01/2017 - 06/2011
3	LigandsIBA 01/2013 - 05/2009
2	Monoamine Oxidase (MAO)IBA 01/2022 - 01/2021
2	RotenoneIBA 01/2022 - 07/2010
2	AminesIBA 12/2021 - 02/2015
2	Ribosomal DNA (rDNA)IBA 01/2021 - 08/2017
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 08/2017
2	ITH12674IBA 02/2020 - 02/2017
2	Meropenem (Merrem)FDA LinkGeneric 01/2020 - 01/2017
2	Carbapenems (Carbapenem Antibiotics)IBA 01/2020 - 01/2017
2	Pharmaceutical PreparationsIBA 01/2020 - 02/2017
2	Amyloid (Amyloid Fibrils)IBA 01/2018 - 09/2004
2	Cholinesterases (Cholinesterase)IBA 04/2017 - 11/2016
2	ITH14001IBA 01/2017 - 01/2017
2	Glutamic Acid (Glutamate)FDA Link 01/2017 - 12/2015
2	Thalidomide (Thalomid)FDA Link 04/2012 - 02/2012
1	OligomycinsIBA 01/2022
1	AcidsIBA 01/2022
1	Oxidoreductases (Dehydrogenase)IBA 01/2022
1	NAD(P)H Dehydrogenase (Quinone) (Quinone Reductase)IBA 01/2022
1	ChloridesIBA 12/2021
1	CurcuminIBA 12/2021
1	piperlongumineIBA 12/2021
1	CamptothecinIBA 10/2021
1	luotonin AIBA 10/2021
1	AlkaloidsIBA 10/2021
1	CyclodextrinsIBA 10/2021
1	Biomarkers (Surrogate Marker)IBA 01/2021
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	Carbon MonoxideIBA 01/2021
1	Lipopolysaccharide ReceptorsIBA 01/2021
1	Phosphotransferases (Kinase)IBA 07/2020
1	tau Proteins (tau Protein)IBA 07/2020
1	Retinaldehyde (Retinal)IBA 02/2020
1	Caspase 3 (Caspase-3)IBA 08/2019
1	sulforaphaneIBA 01/2019
1	phenylhydrazine (phenylhydrazine hydrochloride)IBA 01/2019
1	Heme (Haem)IBA 01/2019
1	Hemoglobins (Hemoglobin)IBA 01/2019
1	Cisplatin (Platino)FDA LinkGeneric 10/2018
1	PlatinumIBA 10/2018
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	Presenilin-1IBA 01/2018
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2017
1	GlutamatesIBA 04/2017
1	Calcium Channels (Calcium Channel)IBA 04/2017
1	inulin trinicotinate monomethochloride (L-3)IBA 04/2017
1	Donepezil (Aricept)FDA LinkGeneric 04/2017
1	ProdrugsIBA 02/2017
1	Imipenem FDA Link 01/2017
1	Dihydrotachysterol (AT 10)IBA 01/2017
1	Colistin (Coly-Mycin)FDA Link 01/2017
1	Formaldehyde (Formol)FDA Link 11/2016
1	Cyanides (Isocyanides)IBA 11/2016

Therapy/Procedure

3	Therapeutics 01/2017 - 02/2012
1	Intraperitoneal Injections 01/2019
1	Adjuvant Chemotherapy 10/2018
1	Critical Care (Surgical Intensive Care) 01/2017